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The drugs work by helping the pancreas increase production of insulin to move sugar from the blood into body tissues
N Engl J Med 387(5):433443 Ashrafizadeh M, Yaribeygi H, Atkin SL, Sahebkar A (2019) Effects of newly introduced antidiabetic drugs on autophagy
It is the first dual GIP / GLP-1 receptor agonist approved by the FDA (Mounjaro 2022, Zepbound 2023) and serves as the reference compound for the broader class of multi-incretin analogs
Large compounders, known as 503B outsourcing facilities, are overseen by the FDA
Second, medicinal chemistry programs explicitly aiming to dissociate appetite and reward effects will produce candidate molecules over the next two to three years
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