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The flexible dose-adjustment approach allowing patients to escalate or de-escalate doses of the drug on the basis of their HbA1c and gastrointestinal tolerability (PIONEER-7) aimed to individually optimize efficacy and safety of once-daily oral semaglutide in T2D adults uncontrolled with one or two oral glucose-lowering drugs, compared to 100 mg/day of sitagliptin

Knowing what to expect and how to manage these effects makes the transition smoother

Roehnelt explains how insulin functions in the body, what happens when insulin resistance develops, and why chronically elevated insulin drives inflammation, weight gain, metabolic dysfunction, and disease progression

Specifically, an enzyme called gamma-glutamyl transpeptidase can degrade glutathione into its individual amino acids during digestion