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Under the acceleration of TGF-1, Nox4 mRNA is significantly upregulated and mediates the transformation of fibroblasts into myofibroblasts by activating TGF-1-Smad2/3 signaling, which leads to cardiac fibrosis
Because of the potential of these outliers to distort the overall sample representation in the principal component analysis plot (Extended Data Fig
Glutathione is also important in protecting against liver failure, especially in the context of metabolic diseases where oxidative stress can contribute to severe liver damage
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