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ML Medically reviewed by a UK Superintendent Pharmacist Mohammed Ismail Lakhi MPharm Superintendent Pharmacist at The Care Pharmacy GPhC Registration Number: 2072815 All clinical content published by The Care Pharmacy is reviewed by a UK-registered pharmacist to ensure accuracy and alignment with current UK medical guidance
The 72-week STEP UP trial was a randomised, double-blinded, parallel-group, placebo-controlled, superiority trial designed to evaluate the efficacy of semaglutide 7.2 mg with semaglutide 2.4 mg and placebo as an adjunct to lifestyle intervention
They show promise in treating inflammatory conditions (e.g., osteoarthritis, asthma, psoriasis, Crohns disease, Colitis Ulcerosa, Hashimotos thyroiditis) by suppressing pro-inflammatory cytokines and enhancing immune balance
GLP-1 medications work by: Slowing stomach emptying, which helps patients feel fuller longer Reducing appetite and food cravings Regulating blood sugar levels Improving insulin sensitivity Traditionally, most GLP-1 medications have been delivered through injections
Serious adverse events in trials remain rare and comparable to placebo rates when adjusted for study populations
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