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Accordingly, the DPP-4 protein has been identified in both subcutaneous and visceral adipose tissue, with its expression, particularly in visceral adipocytes, being more pronounced in obese subjects (81)

doi: 10.1097/00000539-200212000-00013 130 LandoniGCalabrMGMarchettiCBignamiEScandroglioAMDedolaEet al

Elevated cell regions were detected by their greater accumulation of the cytoplasmic fluorescent CellTracker dye in comparison to the very thin cellular protrusions

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Inhibition of matrix metalloproteinase 9 (MMP9), which degrades extracellular matrix around the vasculature, rescues this effect