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Oral vitamins must get broken down by the GI tract (through the stomach, and intestines) and then go through the liver for metabolizing

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Lastly, it has been described that hepatic injury caused by APAP is lower in mice with elevated expression of Nrf2 and in those with constitutive activation of LXR 39,41

IL-1R has been found to play an essential role in promoting inflammatory response and subsequent pathogenesis after APAP overdose