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SUSTAIN-6 (NCT01720446), which looked at semaglutide (Ozempic

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They: Increase insulin release when blood sugar rises Decrease glucagon, which helps prevent blood sugar spikes Slow gastric emptying, so food moves more gradually through the digestive tract Increase feelings of fullness and reduce appetite Signal in the brain to influence hunger, cravings, and reward Together, these effects change how your body processes food, regulates energy, and responds to hunger signals

The FDA has been vocal about its concerns in this category