Mechanisms: By enhancing pulsatile GH release and downstream IGF-1 signaling, Tesamorelin promotes lipolysis, especially in visceral fat depots, while supporting metabolic regulation and hepatic lipid metabolism
Yadav P, Sharma P, Sundaram S, Venkatraman G, Bera AK, Karunagaran D
In adults with growth hormone receptor deficiency, eight weeks of rhIGF-1 therapy significantly increased whole-body protein synthesis, decreased protein oxidation and increased lean body mass while reducing fat mass, demonstrating enhanced muscle anabolism and nutrient utilization in humans
doi: 10.3945/ajcn.2010.28674F [PubMed] [Elsevier] 117
Int J Epidemiol (1989) 18(1):459