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Aged-monkey studies reported changes in evening melatonin and cortisol rhythms

EXAMPLE 11 : EFFECT OF HP-B-CD CONCENTRATION ON SUBCUTANEOUS TOLERANCE UPON SUBCUTANEOUS INJECTION This example shows the concentration dependent effect of HP-B-CD on the subcutaneous tissue upon subcutaneous injection

Taking it late in the day may increase alertness or interfere with sleep

A p-value less than 0.05 was considered statistically significant, indicating a meaningful difference in treatment efficacy