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The freeze-thaw process is brutal on peptide chains, causing them to fracture and become useless

Iron deficiency: It may interfere with iron absorption

The formulation chemistry, including buffers, preservatives, and stabilizers, can irritate surrounding tissue upon contact

Haibo Si, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Anyway, for ease of self-injecting we recommend the belly and other places for your B12 shots, such as How to inject vitamin B12 into your belly