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Results typically begin at week 4 to 6 and compound through week 12: because MOTS-c works through mitochondrial gene expression and metabolic pathway activation rather than appetite suppression, the timeline is slower than GLP-1 therapies but produces different, complementary changes in metabolic function

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Nat Med 8(3):240246

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1d,e), which suggests that the ability of the tumour to synthesize intracellular GSH is dispensable