Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice
Moreover, these multi-protein complexes are continuously exposed to a GSH-depleted environment in Gclc -deficient FoB, which might alter protein folding or their targeting to the mitochondria
Comparatively, when these increases are quantified against a placebo baseline of 1.31 mIU/l or 0.4 ng/ml, there seems to be an enhancement that might exceed 60 times the baseline levels
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Jastreboff AM, Kaplan LM, Fras JP, et al