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During puberty, hypothalamic gonadotropin-releasing hormone (GnRH) stimulates the pituitary secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which trigger ovarian estrogen production, marking the onset of estradiol increase and the beginning of ovarian cycles [52]

This means a T2D patient on Ozempic at Kaiser NW has already satisfied a prerequisite for the Wegovy weight-loss PA if they later pursue that route

Hypophosphorylated Rb combines with E2F (a transcription factor), which inhibits E2F transcriptional activity and results in cell cycle arrest

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