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it's about minimizing risk

The first dose is 1000 mcg of vitamin B12 given IM every day for a week

After starting and after each dose increase, tirzepatide can cut the peak absorption of an oral contraceptive by more than half, so the label guidance is a non-oral method or added barrier protection for four weeks after starting and four weeks after each increase. It is a first-dose-and-escalation effect, not a permanent block on all oral drugs

Rehabilitation and Mobility: Structured rehabilitation exercises, resistance training, and mobility work may assist with joint stability, flexibility, and musculoskeletal recovery