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Reported Side Effects and Safety Concerns From Unlicensed Use Retatrutide causes predominantly gastrointestinal side effects, with additional class-level risks including pancreatitis, gallbladder disease, heart rate elevation, and injection site infections
10.1016/S0146-0005(99)80047-0
The protective effect was seen as early as one year and continued through five years of follow-up
It is not a replacement for these medications but rather a different approach targeting a distinct metabolic pathway
This has made it an attractive option for those seeking a more uniform skin tone or lightening hyperpigmentation
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