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3 Results In this study, we aimed to determine if three drugs from the SSRI family (sertraline, fluoxetine, and citalopram), commonly used as antidepressants (Figure 1, right panel), can be repurposed as inhibitors of MRP1 and MRP7 transporters (Figure 1, left panel) to overcome MDR in cancer cells

The plates were then washed with 1 PBS, and cells were lysed with 50 l BioSpyder 1 lysis buffer for 15 min at RT

doi: 10.3390/antiox12020258 17

While the cancer cells provide their microenvironment with secreted metabolites, sertraline treatment could target the galectin-1 mediated immunosuppressive marks of ser/gly metabolically dependent lung cancer [35, 67]

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