Oxidative stress, which results from the imbalance between the production and neutralization of ROS, is also reported to be involved in a large number of pathological states, such as Alzheimers disease [30], Parkinsons disease [31], atherosclerosis [32], heart failure [33], myocardial infarction [34], and hepatic encephalopathy [35]
The medication also induces significant weight loss, with patients losing an average of 15% to 21% of their body weight in the SURMOUNT obesity trials, with somewhat lower weight loss observed in patients with type 2 diabetes
Both albumin fusions extend the plasma half-lives of GLP-1 and FIX by manyfold 30,31,32,81,82
TRIPLE GLUCAGON-LIKE PEPTIDE-1/GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE/GLUCAGON RECEPTOR TRIAGONISTS Undoubtedly, the approval of the first GLP-1 receptor agonist in 2005 has revolutionised the pharmacological treatment of obesity and T2DM
GLP-1 receptor agonists are known to cause gastrointestinal issues , with nausea, vomiting, and diarrhea being the most commonly reported side effects