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Purification, properties, and mechanism of action
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Specific neuropsychiatric symptoms are associated with faster progression in Alzheimers disease: Results of the Prospective Dementia Registry (PRODEM-Austria)
Nature 413 , 171174 (2001)
Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]
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