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JAMA 320 (19), 20102019
A study demonstrated that daily doses reduced HbA1c by 1.2% over 26 weeks
The minimum effective drug holiday appears to be four weeks, with six weeks providing a more complete reset based on pharmacokinetic clearance data
Therefore, the sponsors concluded that clinically significant DDIs mediated by direct inhibition of CYP enzymes or transporters are unlikely to occur with the administration of GLP-1 RAs and a dual GLP-1/GIP RA
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