In addition to normal tissues, it has been reported that GPx2 is upregulated in a variety of tumor cells [76, 95] and is associated with tumor cell proliferation and poor prognosis of patients [96, 97]
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Antioxid Redox Signal 19 , 15391605 (2013)
Precursor recycling (e.g., NR, NMN) also wanes due to reduced enzyme efficiency in salvage pathways
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