During the ischemic phase, oxygen and nutrient deprivation induces cells to transition from aerobic metabolism to anaerobic glycolysis, leading to rapid depletion of adenosine triphosphate (ATP), intracellular acidosis, and lactic acid accumulation 4,5
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Additionally, the glutathione peroxidases play a critical role in thyroid function because they catalyze the degradation of peroxides generated during thyroid hormone synthesis (10)
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