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Ipamorelin is a synthetic pentapeptide that selectively stimulates the release of growth hormone (GH) from the pituitary gland by mimicking ghrelin and binding to the GHS-R (growth hormone secretagogue receptor)
Mice exposed to chronic unpredictable mild stress (CUMS) for 6 weeks showed increased hypothalamic corticotropin-releasing hormone concentrations, elevated corticosterone levels and increased blood ammonia, which corresponded with anxiety-like behaviors, demonstrating HPA axis involvement in anxiety pathogenesis (Jia et al., 2024)
Characterization of clinical manifestations in the co-occurring phenotype of attention deficit/hyperactivity disorder and autism spectrum disorder
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