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SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma

Limitations of Use : Since the long-term cardiovascular safety and potential long-term cardiovascular benefit of tesamorelin treatment have not been studied and are not known, careful consideration should be given whether to continue tesamorelin treatment in patients who do not show a clear efficacy response as judged by the degree of reduction in visceral adipose tissue measured by waist circumference or CT scan

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This is an important consideration for future studies due to the larger effect size in risk of PDAC observed in patients with new onset compared with longstanding diabetes (typically defined as 3 years duration) 46

We also lacked information on ethnicity, an established risk factor for prostate cancer