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But previous studies have shown that increased citrulline directly binds to JAK2 and inhibits JAK2-STAT1 signalling ( 1,5-AG is one of the main polyol sugars in the human body, is mainly derived from food and is hardly synthesized by the human body (Yamanouchi and Akanuma, 1994)

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(PubMed) Ramaekers VT, Blau N, Sequeira JM, Nassogne MC, Quadros EV