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10.1016/j.ejphar.2017.09.009 104 MaasA

In addition to the consensus on the prominent role of cystine starvation in blocking GSH synthesis, the present two studies demonstrated two previously under-appreciated metabolic effects that contribute to the ferroptosis-susceptible state in cancer cells under cystine deprivation conditions: loss of GPX4 protein translation and accumulation of oxidative stress-inducing intracellular glutamate (Fig

Awano N, Wada M, Kohdoh A, Oikawa T, Takagi H, Nakamori S

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