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Mycobacterium tuberculosis produces D-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Yet another small molecule that has been studied extensively as a highly potent small molecule inhibitor of both human and murine CD38 is 78c, which has been shown to be 10-fold less potent against the cyclase activity than the hydrolase activity of recombinant human CD38 139
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MASLD is the most common cause of chronic liver disease, and affects nearly 40% of adults in Singapore
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