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Given the potential for GLP-1 RA to affect heart rates [30], a meta-analysis of 43 RCTs using GLP-1 RAs showed no increased risk of AF with GLP-1 RAs [39]

However, activators of this receptor also are gaining attention due to their ability to protect nerve cells from damage, promote nerve cell growth, and boost the integrity of the blood-brain-barrier, a tight, semi-permeable membrane that controls which substances in the bloodstream can get into the brain

King P, Peacock I, Donnelly R

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At the European Congress on Obesity in 2026, researchers presented a further analysis looking at a specific subgroup of patients