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Consequently, there is an elevation in synaptic concentrations of these neurotransmitters which enhances excitatory potential transmission at neural synaptic endings to ameliorate depressive symptoms (Yang et al., 2021)

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174 Interestingly, some emerging evidence suggests protein restriction may not be as important for patients being treated with RAAS inhibitors and SGLT2 inhibitors, and several leading guidelines do not recommend any protein restriction for people with CKD, although excess protein intake is often discouraged

These differ from the localized histamine responses discussed earlier