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centrally-mediated loss of appetite & increased thermogenic activity GLP-1 receptors are found in regions of the hindbrain and hypothalamus that regulate feeding behavior Centrally mediated GLP-1 effects include: reduction of food intake - resulting in weight loss due to reduced caloric intake activation of sympathetic pathways in the dorsomedial hypothalamus (DMH) and ventromedial nucleus of the hypothalamus (VMH) that increase neuronally mediated thermogenic activity of brown adipose tissue (BAT) resulting in increased energy expenditure with associated weight loss (Contreras et al, 2017
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Phentermine increases heart rate and blood pressure through its sympathomimetic activity, while semaglutide has been associated with modest increases in heart rate (average 1-4 beats per minute) in clinical trials
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10.1016/j.pbb.2006.09.008 Pharmacol Biochem Behav
