These protective effects are attributed to honeys antioxidant properties (elevate glutathione, SOD), anti-inflammatory actions (decrease IL-6, TNF-) (138, 139), and its capacity to modulate gut microbiota composition (enhance Lactobacillus spp.) (140)
MACE-5 (all-cause death, MI, stroke, heart failure event, coronary revascularisation) 44 events on retatrutide, 52 on placebo: In-study: HR 0.82 (95% CI 0.551.22) On-treatment: HR 0.73 (95% CI 0.471.12) MACE-3 (CV death, MI, stroke) 27 events on retatrutide, 23 on placebo: In-study: HR 1.12 (95% CI 0.641.96) On-treatment: HR 0.92 (95% CI 0.511.65) Lilly states plainly that MACE occurred less frequently than anticipated in both arms
Peroxide value serves as a practical indicator, with low values consistent with minimal oxidative burden and values approaching or exceeding approximately 20 mEq O 2 /kg fat indicating substantial oxidation that reduces the likelihood of postbiotic-like effects
Finally, the remaining papers studied patients with alcohol use disorder (2), anorexia nervosa (1), acquired hypothalamic damage (1), Prader-Willi syndrome (1), and major depressive disorder (1)