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Creatine monohydrate (35 g daily) is the most evidence-backed supplement for muscle preservation during caloric deficit

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Finally, if you're taking any other prescription medications, it's always best to consult a physician or pharmacist before starting supplements, as some over-the-counter supplements can interact with prescription medications

12-14 Titers tended to be low at week 30 and did not predict response to therapy or incidence of side effects or other safety issues