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Receptor autophosphorylation, downstream phosphorylation of IRS-1 and Shc, and activation of PI3K and MAPK occur with similar kinetics to native IGF-1 once the ligand reaches the receptor
This happens through its ability to inhibit melanin production, which can gradually reduce pigmentation, tanning, and uneven skin tone
[4] Yeh MY, Burnham EL, Moss M, Brown LA
This regulatory status is one of the most important parts of its safety picture
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