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Wu S, Chang G, Gao L, Jiang D, Wang L, Li G, et al
Afamelanotide received EMA approval in Europe (2014) and FDA approval in the United States (2019) for EPP making it the only melanocortin peptide to reach full regulatory approval to date
Its altered IGFBP binding profile makes it a useful tool for studying IGF-1 receptor activation independent of binding-protein dynamics
And comparing them meaningfully is harder than it looks - the differences that actually matter aren't the ones the marketing pages lead with
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