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Despite their groundbreaking impact, these medications often require frequent administration due to their short half-lives and the necessity of maintaining consistent therapeutic levels 15

Indication(s): Wegovy is FDA-approved for chronic weight management in adults with obesity or adults with overweight who have a related health condition, such as high blood pressure, type 2 diabetes, or high cholesterol

But combined with dietary changes and exercise, the berberine component in particular may provide an incremental benefit

Gomez DR, Tang C, Zhang J, Blumenschein GR Jr, Hernandez M, Lee JJ, Ye R, Palma DA, Louie AV, Camidge DR, Doebele RC, Skoulidis F, Gaspar LE, Welsh JW, Gibbons DL, Karam JA, Kavanagh BD, Tsao AS, Sepesi B, Swisher SG , Heymach JV

Both routes now exist