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It works by selectively binding to the ghrelin receptor (GHS-R1a) a key trigger in the GH release cascade

For example, chronic butyrate administration reduces food intake and body weight via a neural gutbrain axis 280

These findings have led to greater interest in understanding the underlying mechanisms of targeting the GIP receptor

According to FDA prescribing information and clinical trial data, the most common adverse reactions include nausea, diarrhea, vomiting, constipation, abdominal pain, and decreased appetite

Neuroendocrinology of reward in anorexia nervosa and bulimia nervosa: beyond leptin and ghrelin