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For example, Chinese formulations such as Xiaoyaosan and Danzhi-Xiaoyao-San have demonstrated the ability to regulate gut microbiota in animal models, leading to improved depressive behaviors

Planned Breaks: What the Evidence Shows Clinical data increasingly supports long-term semaglutide use rather than temporary treatment followed by discontinuation

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Most human studies rely on small sample sizes, short intervention periods, and subjective appetite or liking scales, while lacking objective gustatory measures such as taste-threshold testing or electrogustometry (153, 173, 180, 181)