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MOTS-c: The Mitochondrial Powerhouse MOTS-c is a mitochondrial-derived peptide (MDP) that plays a critical role in regulating energy production and metabolic health
The central mechanism involves both homeostatic (energy balance) and hedonic (food reward) pathways, providing comprehensive appetite regulation
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Published human evidence includes topical applications over defined periods, diabetic-ulcer wound protocols, and a registered topical acute-wound trial, while there is no FDA-approved injectable GHK-Cu label that establishes a standard dose [2], [3], [7], [8]
N Engl J Med 1975;292:282-4
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