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Tirzepatide is formulated to mimic the function of native GIP at the GIPR while also interacting with the GLP1R in a manner different from native GLP1

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The consequences of these maladaptive changes are increase in myocardial stiffness and reduced ventricular compliance which play a vital role in the development of LV diastolic dysfunction leading to heart failure with preserved ejection fraction (HFpEF), the most common form of HF in T2DM (40)

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