Injectable options provide better outcomes for patients seeking significant weight loss
In addition to GLP-1 agonists, there have also been recent developments in oral GLP-1 therapies, dual agonists (GLP-1 and/or glucose-dependent insulinotropic polypeptides), and expanded therapeutic uses
Crosses the blood-brain barrier
The review contextualised native GLP-1 as the reference molecule for the entire dual GIP/GLP-1 receptor agonist research field including tirzepatide (approved) and novel triple agonists targeting GLP-1R, GIPR, and GCGR simultaneously confirming native GLP-1s ongoing research importance as the pharmacological anchor of this rapidly expanding compound class
Breastfeeding Previous serious allergic reaction to any GLP-1 medication Type 1 diabetes (no FDA approval for T1D, though some physicians prescribe off-label) If you take insulin, sulfonylureas, or meglitinides alongside a GLP-1, the risk of hypoglycemia increases