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Same incretin pathway Little added efficacy More cost More polypharmacy Rule in practice: stop DPP-4 inhibitor before starting semaglutide unless there is a very unusual reason not to

He explained that the benefits need to be weighed against potential side effects, adding that investigations of side effects become especially important given the broad range of people this medicine and others like it could help

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Ozempic was approved in 2017 to help control blood sugar in people with type 2 diabetes, and is supplied in multidose pens, while Wegovy is for weight loss and available as single use pens 4 , 11