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Phenylalanine and Tyrosine Catabolism Phenylalanine normally has only two fates: incorporation into polypeptide chains, and hydroxylation to tyrosine via the tetrahydrobiopterin-requiring phenylalanine hydroxylase (PAH) reaction

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The immediate goal is to correlate its levels in accessible biofluids with stroke severity and progression, thereby establishing its utility for enriching clinical trials with patients most likely to benefit from ferroptosis inhibition