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These include severe abdominal pain (which could indicate pancreatitis), persistent nausea and vomiting preventing adequate oral intake, or symptoms of gallbladder disease (pain in the upper right abdomen, fever, yellowing of skin/eyes)

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The redox properties of NADs regulate the direction of hundreds of cellular biosynthetic pathways varying from amino acid, lipid and nucleotide synthesis to folate cycle, detoxification reactions of drugs and reactive oxygen species 57