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Non-healing wounds may sometimes indicate: Diabetes or insulin resistance Poor circulation Infection Nutritional deficiencies Autoimmune conditions Vascular disease Pressure injuries Other serious medical concerns These conditions require comprehensive medical evaluation

Non-alcoholic fatty liver disease (NAFLD): assessment and management

The end product of this reaction (AGE), in turn, induce oxidative stress and accelerate the Maillard reactions ultimately leading to inflammation and the propagation of tissue damage [30, 31, 32]