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In previous studies, the expansion of polyglutamine (polyQ) bundles to 36 or more glutamine repeats will cause the HTT protein to misfold and aggregate, leading to neuronal death and symptoms of Huntingtons disease (Mangiarini et al., 1996)

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Draw the structure of glutathione at physiological pH (pH = 7.3)

The results revealed that patients receiving the combined therapy experienced significantly greater improvements compared to those in the control group