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Therapeutic immunomodulation by rationally designed nucleic acids and nucleic acid nanoparticles

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The key preclinical data urgently needed before clinical trials can commence include: (i) efficacy and immune-profiling data derived strictly from clinically relevant orthotopic and spontaneous pulmonary metastasis models, rather than simple ectopic subcutaneous models

Future studies should employ stratified analyses or doseresponse curves to explore the influence of different GSH doses on prognosis, offering guidance for more precise clinical application

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