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Studies have shown that N-terminal modifications of Incretins - specifically changing the second amino acid in the GLP-1 and GIP molecules from Ala to Gly or other amino acid can reduce the rate of DPP-4 inactivation of these peptides without impacting their ability to bind to their cognate receptors (Green and Flatt, 2007)
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doi:10.1177/10600280231205490 59
Diabetes Care (2007) 30:2348
It is important to note that when in the gel helical conformation, CGN has high acid stability, as demonstrated by CGN's application in ready-to-eat water gel desserts, where a long shelf life at pH 4 is required
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