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The second mechanism by which glutathione causes lightening of skin is inhibition of transfer of tyrosinase to premelanosomes for melanin synthesis.[] The third mechanism of tyrosinase inhibition is through its antioxidant effect as it scavenges the free radicals generated in the epidermis following UV light irradiation

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For persistent, unexplained, or worsening skin conditions, a dermatology referral may be appropriate

2014;5:e1083

As outcome, we computed the free energy surfaces and transition probabilities