Since genetic manipulations (e.g., knockdown, knockout, overexpression, etc.) are not possible in RBCs, pharmacological modulation of surface and intracellular proteins by specific antibodies, inhibitors, and agonists remains the only currently available approach
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Additionally, obesity rates alone are expected to increase from 14% to 24% within this timeframe, potentially impacting nearly 2 billion adults, adolescents, and children by 2035