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Notation of interest: Methylcobalamin B12, is often considered beneficial for individuals with Methylenetetrahydrofolate reductase (MTHFR) gene mutation
Nature Reviews Drug Discovery
306). This is likely due to decreased digestive enzyme production or decreased stomach acid resulting in a decreased ability to cleave B12 from its carrier proteins in animal foods
Digestive issues such as Crohn's or celiac disease can lead to impaired absorption of nutrients in the gut which may result in the need for B12 supplementation
Leaky gut and autoimmune diseases Alessio Fasano 1 Clin Nutr
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