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The C-terminal of hormone binds to the extracellular domain, while the N-terminal interacts with the transmembrane domain of the receptor (43)
Of note the prolonged treatment with BSO did not substantially affect the weight of treated mice, suggesting limited undesired effects associated with this regimen
Z Physiol Chem 238 191 1936, Beilstein 4 III 1630, 1632.] References [1]
These pulses drive downstream IGF-1 production in the liver, which mediates many of the metabolic and anabolic effects attributed to GH signaling
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